ceftazidime, Tazidime
Generic name:
• ceftazidime
Brand name:
• Tazidime
Classification:
• Antibiotic
• Cephalosporin (third generation)
Dosage:
• 300 mg
Route:
• IVTT
Frequency:
• q 8 hr
• ANST(-)
MECHANISM OF ACTION:
♥ Inhibits synthesis of bacterial cell wall, causing cell death.
INDICATION:
☻ CNS infections
CONTRAINDICATIONS
☼ Contraindicated to patients with allergies to penicillins, cepahlosporins.
ADVERSE EFFECTS OF THE DRUG
CNS: Headache, dizziness, thethargies, paresthesias
GI: nausea, vomiting, anorexia, abdominal pain, flatulence, psuedomembranous colitis, liver toxicity
GU: Nephrotoxicity
Hematologic: bone marrow depression- decreased WBC, decreased platelets, decrease Hct
Hypersensitivity: ranging from rash to fever to anaphylaxis, serum sickness reaction
Local: Pain, abscess at injection site, phlebitis, inflammation at IV site
Other: Superinfections, disulfiram-like reactions with alcohol
NURSING INTERVENTION and PRECAUTIONS
☻ Assess for liver and renal dysfunction
☻ Culture infection, and arrange sensitivity tests before and during therapy if expected response is not seen.
Warning:
☻ Do not mix with aminoglycoside solutions, administer these drugs separately.
☻ Powder and reconstituted solution darken with storage.
☻ Have Vit. K available in case hypoprothrombinemia occurs
☻ Discontinue if hypersensitivity occurs
☻ Teach SO that patients may experience upset stomach or diarrhea but must report severe diarrhea, difficulty breathing, fatigue, pain at injection site.
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