ceftazidime

Generic name:
• ceftazidime

Brand name:
• Tazidime

Classification:
• Antibiotic
• Cephalosporin (third generation)

Dosage:
• 300 mg

Route:
• IVTT

Frequency:
• q 8 hr
• ANST(-)

MECHANISM OF ACTION:
♥ Inhibits synthesis of bacterial cell wall, causing cell death.

INDICATION:
☻ CNS infections


CONTRAINDICATIONS
☼ Contraindicated to patients with allergies to penicillins, cepahlosporins.


ADVERSE EFFECTS OF THE DRUG
CNS: Headache, dizziness, thethargies, paresthesias

GI: nausea, vomiting, anorexia, abdominal pain, flatulence, psuedomembranous colitis, liver toxicity

GU: Nephrotoxicity

Hematologic: bone marrow depression- decreased WBC, decreased platelets, decrease Hct

Hypersensitivity: ranging from rash to fever to anaphylaxis, serum sickness reaction

Local: Pain, abscess at injection site, phlebitis, inflammation at IV site

Other: Superinfections, disulfiram-like reactions with alcohol

NURSING INTERVENTION and PRECAUTIONS
☻ Assess for liver and renal dysfunction
☻ Culture infection, and arrange sensitivity tests before and during therapy if expected response is not seen.
Warning:

☻ Do not mix with aminoglycoside solutions, administer these drugs separately.
☻ Powder and reconstituted solution darken with storage.
☻ Have Vit. K available in case hypoprothrombinemia occurs
☻ Discontinue if hypersensitivity occurs
☻ Teach SO that patients may experience upset stomach or diarrhea but must report severe diarrhea, difficulty breathing, fatigue, pain at injection site.